Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.44 |
| ▸ | QDPR | P09417 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014339 | 0.89 | PDE4B (0.46) | PDE4BQDPRLMNAADAM17ADAMTS5 | |
| SCHEMBL9014384 | 0.84 | ADAM17 (0.47) | PDE4BQDPRLMNAADAM17ADAMTS5 | |
| SCHEMBL9014717 | 0.82 | ABCB1 (0.48) | PDE4BQDPR | |
| SCHEMBL9014714 | 0.82 | KCNH2 (0.56) | TLR7 | |
| SCHEMBL9233397 | 0.82 | ADAM17 (0.47) | PDE4BQDPRLMNAADAM17ADAMTS5 | |
| SCHEMBL9014334 | 0.79 | KCNH2 (0.46) | PDE4BQDPRLMNAADAM17ADAMTS5 | |
| SCHEMBL9014711 | 0.76 | PTGDR2 (0.51) | PDE4BQDPRADAM17ADAMTS5PDE4A | |
| SCHEMBL9014710 | 0.74 | PTGDR2 (0.52) | PDE4BQDPR | |
| SCHEMBL9014309 | 0.72 | KCNH2 (0.59) | PDE4BQDPR | |
| SCHEMBL9015280 | 0.70 | KCNH2 (0.66) | QDPRTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |