Terephthalic Acid

Terephthalic Acid

SCHEMBL9014429

O=C(O)c1ccc(C(=O)O)cc1.Oc1cccc(-c2ccccc2)c1O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.59
ALDH1A1 P00352 2/20 0.52
HPGD P15428 2/20 0.52
HSD17B10 Q99714 2/20 0.52
BCL2L1 Q07817 1/20 0.52
HDAC4 P56524 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
EGFR P00533 1/20 0.49
TTR P02766 3/20 0.47
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
TSHR P16473 3/20 0.46
DAO P14920 1/20 0.46
NAPRT Q6XQN6 1/20 0.46
TRPA1 O75762 1/20 0.46
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1685024 0.96 HNF4A (0.56) HNF4AALDH1A1HPGDHSD17B10BCL2L1
Benzoic Acid SCHEMBL9033308 0.96 HNF4A (0.59) HNF4AALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL10598796 0.94 TTR (0.52) HNF4AALDH1A1HPGDHSD17B10BCL2L1
Bicarbonate SCHEMBL27723911 0.88 HNF4A (0.62) HNF4AALDH1A1HPGDHSD17B10BCL2L1
2-Phenylphenol SCHEMBL9013767 0.86 ALDH1A1 (0.71) HNF4AALDH1A1HPGDHSD17B10BCL2L1
Oxalic Acid SCHEMBL28580275 0.86 HNF4A (0.60) HNF4AALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL94298 0.86 ALDH1A1 (0.68) HNF4AALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL29365218 0.86 ALDH1A1 (0.68) HNF4AALDH1A1HPGDHSD17B10BCL2L1
Terephthalamide SCHEMBL27742365 0.86 HNF4A (0.51) HNF4AALDH1A1HPGDHSD17B10BCL2L1
Benzophenone SCHEMBL27523577 0.85 HNF4A (0.55) HNF4AALDH1A1HPGDHSD17B10BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0745233-A1 CURE CONTROLLED CATALYZED MIXTURES OF EPOXY RESINS AND CURING AGENTS CONTAINING MESOGENIC MOIETIES, B-STAGED AND CURED PRODUCTS THEREFROM THE DOW CHEMICAL COMPANY (US) 1996-12-04 EP disclosed
WO-1995022079-A1 CURE CONTROLLED CATALYZED MIXTURES OF EPOXY RESINS AND CURING AGENTS CONTAINING MESOGENIC MOIETIES, B-STAGED AND CURED PRODUCTS THEREFROM THE DOW CHEMICAL COMPANY (US) 1995-08-17 WO disclosed