Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Phenylphenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | BLVRB | P30043 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Phenylphenol SCHEMBL150515 | 0.96 | ALDH1A1 (0.71) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| SCHEMBL2038730 | 0.96 | HSD17B10 (0.64) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| SCHEMBL29876739 | 0.96 | HSD17B10 (0.64) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| 2-Phenylphenol SCHEMBL27898045 | 0.94 | BCL2L1 (0.63) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| Terephthalic Acid SCHEMBL9014425 | 0.89 | TSHR (0.59) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| 2-Phenylphenol SCHEMBL27504029 | 0.87 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10TSHR | |
| 2-Phenylphenol SCHEMBL2415939 | 0.87 | ALDH1A1 (0.85) | ALDH1A1HPGDBCL2L1HSD17B10TSHR | |
| 2-Phenylphenol SCHEMBL27535989 | 0.87 | ALDH1A1 (0.56) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| Terephthalic Acid SCHEMBL9014429 | 0.86 | HNF4A (0.59) | ALDH1A1HPGDBCL2L1HSD17B10EGFR | |
| Hydrochloric Acid SCHEMBL28535972 | 0.86 | EGFR (0.56) | ALDH1A1HPGDBCL2L1HSD17B10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745233-A1 | CURE CONTROLLED CATALYZED MIXTURES OF EPOXY RESINS AND CURING AGENTS CONTAINING MESOGENIC MOIETIES, B-STAGED AND CURED PRODUCTS THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995022079-A1 | CURE CONTROLLED CATALYZED MIXTURES OF EPOXY RESINS AND CURING AGENTS CONTAINING MESOGENIC MOIETIES, B-STAGED AND CURED PRODUCTS THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1995-08-17 | — | — | WO | disclosed |