Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | BTN3A1 | O00481 | 2/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28167617 | 0.87 | PRKCA (0.38) | PRKCABTN3A1GAA | |
| SCHEMBL5270258 | 0.83 | PRKCA (0.36) | ALDH1A1LMNAHSD17B10PRKCABTN3A1 | |
| SCHEMBL10013020 | 0.80 | ALOX15 (0.40) | ALDH1A1ALOX15LMNAHSD17B10PRKCA | |
| SCHEMBL10735935 | 0.80 | PRKCA (0.34) | PRKCA | |
| SCHEMBL4441418 | 0.80 | ALDH1A1 (0.43) | ALDH1A1ALOX15LMNAHSD17B10PGR | |
| SCHEMBL11201836 | 0.79 | ALDH1A1 (0.48) | ALDH1A1ALOX15LMNAHSD17B10PRKCA | |
| SCHEMBL4156482 | 0.78 | PRKCA (0.31) | PRKCA | |
| SCHEMBL4705394 | 0.77 | ALDH1A1 (0.39) | ALDH1A1TSHR | |
| SCHEMBL9691314 | 0.74 | ALDH1A1 (0.39) | ALDH1A1ALOX15LMNAHSD17B10PGR | |
| SCHEMBL450210 | 0.73 | ELANE (0.32) | PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510367-A | TREATMENT OR PREVENTION OF NEUROTOXIC INJURIES SUCH AS CEREBRAL STROKE, HEMMORHAGIC STROKE, CEREBRAL ISCHEMIA, VASOSPASM, HYPOGLYCEMIA, ANAESIA, HYPOXIA, ASHYXIA, CARDIAC ARREST AND NEURODEGENERATIVE DISEASES | GLAXO SPA (IT) | 1996-04-23 | — | — | US | disclosed |
| US-5374649-A | Nervous system disorders | GLAXO S.P.A. (IT) | 1994-12-20 | — | — | US | disclosed |
| US-5373018-A | Antagonist to excitory amino acids on N-methyl aspartic acid receptor complex, theraputically effective in treatment of central nervous system disorder | GLAXO S.P.A. (IT) | 1994-12-13 | — | — | US | disclosed |
| EP-0568136-A1 | Indole-2-carboxylic acid derivatives | GLAXO S.p.A. (IT) | 1993-11-03 | — | — | EP | disclosed |
| WO-1993021153-A1 | INDOLE-2-CARBOXYLIC ACID DERIVATIVES | GLAXO S.P.A. (IT) | 1993-10-28 | — | — | WO | disclosed |
| US-4075203-A | Process for preparing a 3-exomethylenecepham sulfoxide from penicillin sulfoxides | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |