Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.30 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463361 | 0.82 | GABRR1 (0.46) | TDP1TGFBR1GABRR1SLC7A5GRIK1 | |
| SCHEMBL17336351 | 0.79 | CPB2 (0.42) | TDP1TGFBR1GABRR1TSHRLMNA | |
| SCHEMBL4603941 | 0.78 | TGFBR1 (0.38) | TDP1TGFBR1TSHRADRA1A | |
| SCHEMBL5678264 | 0.77 | GSR (0.48) | GABRR1LMNA | |
| SCHEMBL27653781 | 0.76 | TDP1 (0.40) | TDP1TGFBR1GRIK1GRIK2GRM1 | |
| SCHEMBL17335986 | 0.76 | CPB2 (0.47) | GABRR1LMNA | |
| SCHEMBL17335976 | 0.76 | CPB2 (0.47) | GABRR1LMNA | |
| SCHEMBL8713920 | 0.76 | CPB2 (0.47) | GABRR1LMNA | |
| SCHEMBL17335968 | 0.76 | CPB2 (0.47) | GABRR1LMNA | |
| SCHEMBL17335987 | 0.76 | CPB2 (0.47) | GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603268-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB (US) | 1996-12-18 | — | — | EP | claimed |
| US-5451617-A | Wettable silicone hydrogel compositions and methods for their manufacture | BAUSCH & LOMB INCORPORATED (US) | 1995-09-19 | — | — | US | claimed |
| EP-0603268-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB (US) | 1996-12-18 | — | — | EP | disclosed |
| US-5451617-A | Wettable silicone hydrogel compositions and methods for their manufacture | BAUSCH & LOMB INCORPORATED (US) | 1995-09-19 | — | — | US | disclosed |