Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901581 | 0.79 | MAP4K4 (0.52) | IDO1MAP4K4MINK1TNIKMAPT | |
| SCHEMBL21201421 | 0.76 | IDO1 (0.37) | IDO1MAP4K4SYKKMOMAPK14 | |
| SCHEMBL5671643 | 0.74 | KMO (0.50) | IDO1MAP4K4MINK1TNIKKMO | |
| SCHEMBL28155744 | 0.74 | IDO1 (0.51) | IDO1MAP4K4MINK1TNIKMAPT | |
| SCHEMBL16675045 | 0.74 | RAB9A (0.44) | IDO1MAPTADORA2A | |
| SCHEMBL2502957 | 0.74 | RAB9A (0.47) | IDO1MAPT | |
| SCHEMBL22068158 | 0.72 | IDO1 (0.55) | IDO1MAP4K4MINK1TNIKMAPT | |
| SCHEMBL19831019 | 0.72 | IDO1 (0.55) | IDO1MAPT | |
| SCHEMBL15571062 | 0.72 | ALDH1A1 (0.43) | MAPTMAPK1 | |
| SCHEMBL30835005 | 0.72 | IDO1 (0.55) | IDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |