Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1B | Q92523 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015962 | 0.87 | CPT1B (0.75) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL2885813 | 0.85 | CPT1B (1.00) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9015980 | 0.85 | CPT1B (0.73) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9623012 | 0.84 | CPT1B (0.56) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9015998 | 0.83 | CPT1B (0.93) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9015974 | 0.81 | CPT1B (0.73) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL11403123 | 0.80 | KDM4E (0.69) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| Fumaric Acid SCHEMBL29802140 | 0.79 | CPT1B (0.86) | CPT1BTDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8102803 | 0.78 | CPT1B (0.60) | CPT1B | |
| SCHEMBL9015960 | 0.77 | CPT1B (0.73) | CPT1BTDP1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283246-A | Trimetazidine compounds | ADIR ET COMPAGNIE (FR) | 1994-02-01 | — | — | US | claimed |
| EP-0533579-B1 | Trimetazidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5283246-A | Trimetazidine compounds | ADIR ET COMPAGNIE (FR) | 1994-02-01 | — | — | US | disclosed |
| EP-0533579-A1 | Trimetazidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-03-24 | — | — | EP | disclosed |