Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A known ✓ | Q03164 | 6/20 | 0.55 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885813 | 0.93 | CPT1B (1.00) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015998 | 0.89 | CPT1B (0.93) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015962 | 0.80 | CPT1B (0.75) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9623027 | 0.79 | CPT1B (0.74) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015995 | 0.79 | CPT1B (0.74) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015960 | 0.78 | CPT1B (0.73) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015980 | 0.78 | CPT1B (0.73) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9015974 | 0.78 | CPT1B (0.73) | CPT1BTDP1MEN1KMT2AALDH1A1 | |
| Fumaric Acid SCHEMBL9296210 | 0.77 | MEN1 (0.54) | CPT1BMEN1KMT2AALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL9296208 | 0.77 | MEN1 (0.54) | CPT1BMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12133720-B2 | Methods and compositions for restoring homeostatic capacity of a subject | Palo Alto Investors LP (US) | 2024-11-05 | — | — | US | disclosed |
| WO-2022190064-A1 | METHODS FOR IDENTIFYING SUBJECTS WITH BETACORONAVIRUS INFECTIONS WHO ARE AT RISK OF ACUTE RESPIRATORY SYNDROME AND METHODS FOR THE TREATMENT OF SAME | VEXO PHARMACEUTICALS DMCC (AE) | 2022-09-15 | — | — | WO | disclosed |