Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033337 | 0.76 | HSD11B1 (0.52) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL3280826 | 0.74 | ALDH1A1 (0.35) | HSD11B1EPHX1 | |
| SCHEMBL7927543 | 0.68 | HSD11B1 (0.48) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL5350579 | 0.67 | HSD11B1 (0.52) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL3905357 | 0.65 | HSD11B1 (0.46) | HSD11B1EPHX1CYP2C9EPHX2 | |
| SCHEMBL21392343 | 0.65 | HSD11B1 (0.46) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL7927539 | 0.65 | HSD11B1 (0.46) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL6670021 | 0.65 | HSD11B1 (0.50) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 | |
| SCHEMBL3753073 | 0.65 | HSD11B1 (0.50) | HSD11B1EPHX1CYP2C9EPHX2 | |
| SCHEMBL1155595 | 0.65 | HSD11B1 (0.50) | HSD11B1EPHX1CYP2C9HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508432-A | TREATING GASTROINTESTINAL DISORDERS, CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO WELLCOME INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5380872-A | Appetite suppresant, gall bladder disorders, CNS disorders | GLAXO INC. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5346907-A | Cholecystokinin antagonists used in treatment or prevention of disorders of gastrointestinal, central nervous, appetite regulating or pain regulating systems | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |