Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1361699 | 0.85 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL28571587 | 0.82 | VCAM1 (0.51) | TDP1ATMALDH1A1VCAM1RAB9A | |
| SCHEMBL2416493 | 0.82 | ATM (0.42) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL7550938 | 0.82 | VCAM1 (0.47) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL1749233 | 0.79 | VCAM1 (0.47) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL26928091 | 0.79 | TDP1 (0.42) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL9899689 | 0.79 | TDP1 (0.42) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL1850626 | 0.78 | ALDH1A1 (0.47) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL57498 | 0.76 | TDP1 (0.54) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL29361654 | 0.76 | TDP1 (0.54) | TDP1ATMALDH1A1HIF1AVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283661-B | 2, 3-Difluoro-6- (trifluoromethyl) -benzonitrile compound and preparation method thereof | 江苏广域化学有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-116283661-A | 2, 3-difluoro-6- (trifluoromethyl) -benzonitrile compound and preparation method thereof | 江苏广域化学有限公司 | 2023-06-23 | — | — | CN | claimed |
| EP-0608713-B1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AG (DE) | 1996-12-27 | — | — | EP | claimed |
| US-5478963-A | 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | claimed |
| EP-0608713-A1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-03 | — | — | EP | claimed |
| JP-7002751-A | — | — | None | — | — | JP | disclosed |
| US-20260078135-A1 | POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 | ENLIVEN INC (US) | 2026-03-19 | — | — | US | disclosed |
| EP-4587124-A1 | POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 | Enliven Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| CN-116283661-B | 2, 3-Difluoro-6- (trifluoromethyl) -benzonitrile compound and preparation method thereof | 江苏广域化学有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-116283661-B | 2, 3-Difluoro-6- (trifluoromethyl) -benzonitrile compound and preparation method thereof | 江苏广域化学有限公司 | 2025-05-09 | — | — | CN | disclosed |
| EP-4426697-A1 | FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-118103370-A | Fused tetracyclic quinazoline derivatives as ERBB2 inhibitors | 英莱汶公司 | 2024-05-28 | — | — | CN | disclosed |
| EP-0608713-B1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AG (DE) | 1996-12-27 | — | — | EP | disclosed |
| US-5478963-A | 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5478963-A | 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5478963-A | 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | disclosed |
| JP-H072751-A | 2,3-DIFLUORO-6-NITROBENZONITRILE AND 2-CHLORO-5,6-DIFLUOROBENZONITRILE(2,3-DIFLUORO-6-CHLOROBENZONITRILE), THEIR PREPARATION AND THEIR USE FOR PREPARATION OF 2,3,6-TRIFLUOROBENZOIC ACID | HOECHST AG | 1995-01-06 | — | — | JP | disclosed |
| EP-0608713-A1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-03 | — | — | EP | disclosed |
| EP-0608713-A1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-03 | — | — | EP | disclosed |
| EP-0608713-A1 | 2,3-Difluoro-6-introbenzonitrile and 2-chloro-5,6-difluorobenzonitrile, process for their preparation and their use in the preparation of 2,3,6-trifluorobenzoic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260078135-A1 | POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 | ERBB2, BRCA1, ERBB3 | TDP1 2757/4885ATM 1440/4885ALDH1A1 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.