Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755605 | 0.89 | KARS1 (0.52) | KARS1BPTFATRDYRK1APRKD1 | |
| SCHEMBL901967 | 0.87 | PRKD1 (0.48) | KARS1BPTFATRPIM1DYRK1A | |
| SCHEMBL901954 | 0.85 | FAAH (0.41) | KARS1MAPK1DYRK1A | |
| SCHEMBL1704872 | 0.85 | KARS1 (0.48) | KARS1BPTFDYRK1APRKD1 | |
| SCHEMBL901708 | 0.85 | KARS1 (0.66) | KARS1DYRK1APRKD1 | |
| SCHEMBL901861 | 0.83 | KARS1 (0.66) | KARS1DYRK1APRKD1 | |
| SCHEMBL1704806 | 0.81 | CKS1B (0.47) | — | |
| SCHEMBL902548 | 0.74 | JAK2 (0.41) | KARS1PRKD1 | |
| SCHEMBL902032 | 0.73 | KARS1 (0.52) | KARS1PIM1CDK6PRKD1 | |
| SCHEMBL901736 | 0.73 | KARS1 (0.51) | KARS1PIM1PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |