Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.48 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901300 | 0.87 | KARS1 (0.49) | KARS1PRKCI | |
| SCHEMBL1755670 | 0.86 | KARS1 (0.40) | KARS1ROCK1ROCK2 | |
| SCHEMBL901236 | 0.86 | KARS1 (0.40) | KARS1ROCK1ROCK2 | |
| SCHEMBL901708 | 0.85 | KARS1 (0.66) | KARS1 | |
| SCHEMBL12469691 | 0.81 | KARS1 (0.72) | KARS1LATS1ROCK1ROCK2 | |
| SCHEMBL902716 | 0.80 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901301 | 0.80 | KARS1 (0.46) | KARS1 | |
| SCHEMBL1704237 | 0.80 | WNT1 (0.41) | KARS1ROCK1ROCK2 | |
| SCHEMBL1755675 | 0.80 | WNT1 (0.41) | KARS1ROCK1ROCK2 | |
| SCHEMBL901736 | 0.80 | KARS1 (0.51) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |