Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 4/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017061 | 0.88 | FTO (0.64) | FTOPABPC1POLBHTTLCK | |
| SCHEMBL9017088 | 0.86 | FTO (0.58) | FTOPABPC1POLBHTTLCK | |
| SCHEMBL9017111 | 0.85 | KMT2A (0.59) | FTOPABPC1POLBHTTMEN1 | |
| SCHEMBL7712243 | 0.83 | FTO (0.81) | FTOPABPC1POLBHTTLCK | |
| SCHEMBL9017071 | 0.77 | FTO (0.71) | FTOPABPC1POLBHTTLCK | |
| Mitonafide SCHEMBL62046 | 0.75 | FTO (1.00) | FTOPABPC1POLBHTTLCK | |
| Mitonafide SCHEMBL29352711 | 0.75 | FTO (1.00) | FTOPABPC1POLBHTTLCK | |
| Mitonafide SCHEMBL29499462 | 0.75 | FTO (1.00) | FTOPABPC1POLBHTTLCK | |
| SCHEMBL10340122 | 0.74 | FTO (0.63) | FTOPABPC1POLBHTTLCK | |
| Mitonafide SCHEMBL5166813 | 0.74 | FTO (0.98) | FTOPABPC1POLBHTTLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552544-A | 5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and their use | KNOLL AG (DE) | 1996-09-03 | — | — | US | claimed |
| US-5552544-A | 5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and their use | KNOLL AG (DE) | 1996-09-03 | — | — | US | disclosed |
| EP-0268093-A1 | 5-Nitrobenzo[de]isoquinoline-1,3 diones, their preparation and use | KNOLL AG (DE) | 1988-05-25 | — | — | EP | disclosed |