Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9586428 | 0.99 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BRECQLADRB2 | |
| SCHEMBL9195086 | 0.93 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BRECQLHTR2A | |
| SCHEMBL9192958 | 0.93 | ADRA1A (0.69) | ADRA1DADRA1AADRA1BHTR2AHTR2C | |
| SCHEMBL9570990 | 0.91 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL9017200 | 0.90 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BRECQLADRB2 | |
| SCHEMBL9199034 | 0.90 | ADRA1A (0.62) | ADRA1DADRA1AADRA1BHTR2AHTR2C | |
| SCHEMBL9585946 | 0.89 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BRECQLHTR2A | |
| SCHEMBL9194958 | 0.88 | ADRA1A (0.60) | ADRA1DADRA1AADRA1BHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9585658 | 0.88 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BRECQLHTR2A | |
| SCHEMBL9200004 | 0.86 | ADRA1A (0.90) | ADRA1DADRA1AADRA1BLMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522915-B1 | Pyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1996-03-13 | — | — | EP | disclosed |
| EP-0577470-B1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1995-05-24 | — | — | EP | disclosed |
| US-5330985-A | Adrenergic blocking agents; urogenital disorders | SYNTHELABO (FR) | 1994-07-19 | — | — | US | disclosed |
| EP-0577470-A1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1994-01-05 | — | — | EP | disclosed |
| EP-0522915-A1 | Pyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1993-01-13 | — | — | EP | disclosed |