Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.72 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017186 | 0.91 | ADRA1D (0.73) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| Hydrochloric Acid SCHEMBL9586428 | 0.90 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL9200004 | 0.85 | ADRA1A (0.90) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL9192958 | 0.84 | ADRA1A (0.69) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL9195086 | 0.84 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL5597266 | 0.84 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL9199034 | 0.81 | ADRA1A (0.62) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| SCHEMBL9017200 | 0.81 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BHTR1AADRB2 | |
| SCHEMBL9585946 | 0.80 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1ALMNA | |
| Fumaric Acid SCHEMBL5459952 | 0.80 | ADRA1D (0.91) | ADRA1DADRA1AADRA1BHTR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244901-A | Multistage preparation by starting with a phenylpiperazine and an epoxide or chloro alcohol containing a phthalimido group; use to treat disorders involving hyperactivity of the alpha 1-adrenergic system | SYNTHELABO (FR) | 1993-09-14 | — | — | US | disclosed |
| EP-0522915-A1 | Pyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1993-01-13 | — | — | EP | disclosed |