SCHEMBL9017388

SCHEMBL9017388

CC(=O)N(CC(=O)O)Cn1c(-c2ccc(Cl)cc2)c(C#N)c(Cl)c1C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.37
MAPT P10636 2/20 0.37
GRIA2 P42262 1/20 0.34
GRIA4 P48058 1/20 0.34
RXFP1 Q9HBX9 2/20 0.33
KMT2A Q03164 4/20 0.32
MEN1 O00255 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
ALDH1A1 P00352 4/20 0.32
HPGD P15428 4/20 0.32
KDM4E B2RXH2 4/20 0.32
LMNA P02545 2/20 0.32
GAA P10253 2/20 0.32
GLA P06280 1/20 0.32
CRHBP P24387 1/20 0.32
HTT P42858 1/20 0.32
CRHR2 Q13324 1/20 0.32
CNR1 P21554 1/20 0.32
FNTA P49354 2/20 0.32
FNTB P49356 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9422643 0.89 ALDH1A1 (0.38) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL9017304 0.87 POLB (0.36) POLBMAPTRXFP1KMT2AMEN1
SCHEMBL9017291 0.80 DAGLA (0.39) POLBMAPTKMT2AMEN1TDP1
SCHEMBL7494704 0.75 KDM4E (0.39) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL9460809 0.75 POLB (0.39) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL9036743 0.74 KDM4E (0.38) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL8994385 0.74 POLB (0.37) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL5815133 0.74 KDM4E (0.36) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL9460811 0.73 POLB (0.37) POLBMAPTGRIA2GRIA4RXFP1
SCHEMBL9017316 0.73 RXFP1 (0.37) POLBMAPTGRIA2GRIA4RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594942-B1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID CO (US) 1996-09-04 EP claimed