Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isophthalic Acid SCHEMBL14778536 | 0.96 | KMO (0.53) | CYP2C9CYP2C8KDM4ETSHRDAO | |
| Terephthalic Acid SCHEMBL5914459 | 0.90 | KDM4E (0.66) | CYP2C9CYP2C8KDM4ETSHRDAO | |
| Terephthalic Acid SCHEMBL2371036 | 0.90 | TSHR (0.59) | CYP2C9CYP2C8TSHRDAONAPRT | |
| SCHEMBL21801848 | 0.87 | KMO (0.69) | KMOFOLH1 | |
| SCHEMBL10787725 | 0.86 | TTR (0.58) | CYP2C9CYP2C8KDM4ETSHRPTPN1 | |
| SCHEMBL29369532 | 0.86 | FOLH1 (0.59) | CYP2C9CYP2C8KDM4ETSHRPTPN1 | |
| Isophthalic Acid SCHEMBL1250697 | 0.86 | ALDH1A1 (0.67) | CYP2C9KDM4ETSHRDAONAPRT | |
| Isophthalic Acid SCHEMBL9679148 | 0.83 | DAO (0.62) | CYP2C9TSHRDAONAPRTCES2 | |
| Terephthalic Acid SCHEMBL184129 | 0.83 | TSHR (0.68) | CYP2C9TSHRDAONAPRTCES2 | |
| Terephthalic Acid SCHEMBL10927557 | 0.83 | TSHR (0.68) | CYP2C9TSHRDAONAPRTCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674587-A4 | IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA. | HOECHST AG (DE) | 1996-02-28 | — | — | EP | claimed |
| EP-0674587-A1 | IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-04 | — | — | EP | claimed |
| WO-1994013483-A1 | IMPROVED BIAXIALLY ORIENTED COPOLYESTER FILM FOR MAGNETIC RECORDING MEDIA | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-23 | — | — | WO | claimed |