Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017570 | 0.89 | DHODH (0.61) | DHODHMTNR1BMTNR1AMAPTSMN1; SMN2 | |
| SCHEMBL9017561 | 0.84 | DHODH (0.61) | DHODHMTNR1BMTNR1AMAPTSMN1; SMN2 | |
| SCHEMBL9157076 | 0.84 | DHODH (0.64) | DHODHMTNR1BMTNR1AMAPTSMN1; SMN2 | |
| SCHEMBL9017576 | 0.82 | DHODH (0.69) | DHODHMTNR1BMTNR1AMAPTSMN1; SMN2 | |
| SCHEMBL9017569 | 0.82 | DHODH (0.54) | DHODHMTNR1BMTNR1AMAPTPOLB | |
| SCHEMBL9017543 | 0.82 | DHODH (0.65) | DHODHMAPTGAAHDAC3HDAC1 | |
| SCHEMBL9017547 | 0.82 | DHODH (0.61) | DHODHMAPTSMN1; SMN2POLBCYP2C19 | |
| SCHEMBL9017564 | 0.82 | DHODH (0.61) | DHODHMTNR1BMTNR1AMAPTHDAC3 | |
| SCHEMBL9017605 | 0.82 | DHODH (0.61) | DHODHMAPTPOLBCA12CA1 | |
| SCHEMBL9017554 | 0.82 | DHODH (0.61) | DHODHMTNR1BMTNR1AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5389652-A | Antiinflammatory agent | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | disclosed |
| EP-0533573-A2 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-03-24 | — | — | EP | disclosed |