Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.44 |
| ▸ | PNLIP | P16233 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017582 | 0.96 | DHODH (0.52) | DHODHSTK39PNLIPBRAFKDR | |
| SCHEMBL9017547 | 0.86 | DHODH (0.61) | DHODHPNLIPMEN1G6PDCACNA1B | |
| SCHEMBL9017569 | 0.82 | DHODH (0.54) | DHODHBRAFKDRMEN1G6PD | |
| SCHEMBL9017598 | 0.82 | DHODH (0.43) | DHODHBRAFKDRMAPT | |
| SCHEMBL15196662 | 0.80 | DHODH (0.62) | DHODHMEN1KMT2AMAPTTP53 | |
| SCHEMBL9017561 | 0.80 | DHODH (0.61) | DHODHPNLIPMEN1KMT2AMAPT | |
| SCHEMBL9017532 | 0.78 | DHODH (0.55) | DHODHMEN1KMT2AMAPT | |
| SCHEMBL9155031 | 0.78 | DHODH (0.45) | DHODHPNLIPMEN1G6PDCACNA1B | |
| SCHEMBL8857721 | 0.77 | DHODH (0.49) | DHODHMEN1KMT2AMAPTTP53 | |
| SCHEMBL9017570 | 0.77 | DHODH (0.61) | DHODHMEN1KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5389652-A | Antiinflammatory agent | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | disclosed |
| EP-0533573-A2 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-03-24 | — | — | EP | disclosed |