Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 6/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857721 | 0.88 | DHODH (0.49) | DHODHALDH1A1MAPT | |
| SCHEMBL9017547 | 0.83 | DHODH (0.61) | DHODHALDH1A1MAPT | |
| SCHEMBL9017569 | 0.83 | DHODH (0.54) | DHODHKDRALDH1A1BRAFMAPT | |
| SCHEMBL9017556 | 0.82 | DHODH (0.49) | DHODHKDRBRAFMAPT | |
| SCHEMBL9017582 | 0.80 | DHODH (0.52) | DHODHKDRBRAFMAPT | |
| SCHEMBL9017561 | 0.77 | DHODH (0.61) | DHODHALDH1A1MAPT | |
| SCHEMBL9017570 | 0.74 | DHODH (0.61) | DHODHALDH1A1MAPT | |
| SCHEMBL9157076 | 0.74 | DHODH (0.64) | DHODHALDH1A1MAPT | |
| SCHEMBL9017532 | 0.74 | DHODH (0.55) | DHODHALDH1A1MAPT | |
| SCHEMBL9017576 | 0.73 | DHODH (0.69) | DHODHALDH1A1RAF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5389652-A | Antiinflammatory agent | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | disclosed |
| EP-0533573-A2 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-03-24 | — | — | EP | disclosed |