Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376711 | 0.85 | HSD17B10 (0.42) | MAPTPOLBNPC1RAB9ACHUK | |
| SCHEMBL3194739 | 0.85 | MAPT (0.47) | MAPTPOLBNPC1RAB9ACHUK | |
| SCHEMBL10338664 | 0.84 | KDM4C (0.47) | MAPTPOLBNPC1RAB9ACHUK | |
| SCHEMBL4139383 | 0.81 | ALDH1A1 (0.55) | NPC1RAB9ACHUKTSHRHPGD | |
| SCHEMBL1190850 | 0.80 | TSHR (0.49) | NPC1RAB9ATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL16303156 | 0.80 | GAA (0.51) | MAPTLMNAGAATP53 | |
| SCHEMBL16305298 | 0.79 | CA1 (0.46) | NPC1RAB9ACHUKTSHRHPGD | |
| SCHEMBL21214214 | 0.79 | CHUK (0.43) | MAPTPOLBNPC1RAB9ACHUK | |
| SCHEMBL1430982 | 0.79 | HDAC1 (0.46) | MAPTRAB9ACHUKTSHRHPGD | |
| SCHEMBL29290726 | 0.79 | CHUK (0.43) | MAPTPOLBNPC1RAB9ACHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593095-B2 | Methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9255100-B2 | Substituted imidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-09 | — | — | US | disclosed |
| US-20140371194-A1 | METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | THE UNIVERSITY OF KANSAS | 2014-12-18 | — | — | US | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371194-A1 | METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | CRYAB, HSP90B1, SERPINB1 | MAPT 4278/4885POLB 695/4885NPC1 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.