Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.33 |
| ▸ | RELA | Q04206 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017921 | 1.00 | MAPT (0.37) | MAPTNCEH1LMNAHTTALDH1A1 | |
| Maleic Acid SCHEMBL9017929 | 0.95 | MAPT (0.34) | MAPTNCEH1LMNAHTTALDH1A1 | |
| SCHEMBL9017939 | 0.91 | NCEH1 (0.34) | NCEH1LMNAALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL9017940 | 0.91 | NCEH1 (0.34) | NCEH1LMNAALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL9017932 | 0.89 | MAPT (0.31) | MAPT | |
| SCHEMBL9017888 | 0.86 | BCHE (0.35) | NCEH1LMNAALDH1A1SMN1; SMN2BCHE | |
| Dimethylcarbate SCHEMBL9681187 | 0.80 | MAPT (0.36) | MAPTLMNAHTTALDH1A1POLB | |
| Dimethylcarbate SCHEMBL9681182 | 0.80 | MAPT (0.36) | MAPTLMNAHTTALDH1A1POLB | |
| SCHEMBL9017925 | 0.78 | MAPT (0.35) | MAPTLMNAHTTALDH1A1POLB | |
| SCHEMBL9017927 | 0.78 | MAPT (0.35) | MAPTLMNAHTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |