Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018368 | 0.97 | GABRA5 (0.46) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9018410 | 0.94 | P4HTM (0.47) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9018542 | 0.92 | GABRA5 (0.49) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9018358 | 0.89 | GABRA5 (0.49) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9018035 | 0.89 | P4HTM (0.58) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9018441 | 0.88 | GABRA5 (0.52) | GABRA5P4HTMPTPN1 | |
| SCHEMBL9018160 | 0.87 | GABRA5 (0.51) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL7871588 | 0.86 | P4HTM (0.51) | GABRA5P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL9017990 | 0.86 | GABRA5 (0.43) | GABRA5P4HTMOPRM1OPRD1GCK | |
| SCHEMBL9140455 | 0.86 | P4HTM (0.55) | GABRA5P4HTMHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |