Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.43 |
| ▸ | GRN | P28799 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018289 | 0.92 | P4HTM (0.46) | GABRA5P4HTMGRNSORT1CXCR1 | |
| SCHEMBL9018316 | 0.90 | CXCR1 (0.45) | GABRA5CXCR1CXCR2RAB9ASMN1; SMN2 | |
| SCHEMBL9018410 | 0.88 | P4HTM (0.47) | GABRA5P4HTMOPRM1OPRD1RAB9A | |
| SCHEMBL9018545 | 0.87 | GABRA5 (0.47) | GABRA5P4HTMGRNSORT1CXCR1 | |
| SCHEMBL9018035 | 0.87 | P4HTM (0.58) | GABRA5P4HTMCXCR2OPRM1OPRD1 | |
| SCHEMBL9018043 | 0.86 | GABRA5 (0.47) | GABRA5P4HTMOPRM1OPRD1GCK | |
| SCHEMBL9018368 | 0.85 | GABRA5 (0.46) | GABRA5P4HTMOPRM1OPRD1GCK | |
| SCHEMBL9143059 | 0.85 | P4HTM (0.53) | P4HTMMCL1RAB9AMAPTNPC1 | |
| SCHEMBL9018441 | 0.83 | GABRA5 (0.52) | GABRA5P4HTMMAPT | |
| SCHEMBL9018180 | 0.82 | RAB9A (0.52) | GABRA5P4HTMMCL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |