Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018398 | 0.91 | GABRA5 (0.55) | GABRA5KCNK3KCNK9PTPN1P4HTM | |
| SCHEMBL9018357 | 0.90 | GABRA5 (0.51) | GABRA5KCNK3KCNK9PTPN1P4HTM | |
| SCHEMBL9018043 | 0.88 | GABRA5 (0.47) | GABRA5PTPN1P4HTM | |
| SCHEMBL9018368 | 0.87 | GABRA5 (0.46) | GABRA5PTPN1P4HTM | |
| SCHEMBL9018410 | 0.85 | P4HTM (0.47) | GABRA5P4HTM | |
| SCHEMBL9017990 | 0.83 | GABRA5 (0.43) | GABRA5P4HTMMAPT | |
| SCHEMBL9018094 | 0.83 | CXCR1 (0.43) | GABRA5 | |
| SCHEMBL9140663 | 0.83 | P4HTM (0.48) | GABRA5PTPN1P4HTMCYP2C9CYP2C19 | |
| SCHEMBL9018172 | 0.83 | MMP8 (0.47) | PTPN1P4HTMMEN1KMT2A | |
| SCHEMBL9018316 | 0.82 | CXCR1 (0.45) | GABRA5CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |