Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018493 | 0.92 | MMP8 (0.49) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9018373 | 0.89 | CXCR2 (0.48) | KMT2AMEN1MAPTGABRA5ALDH1A1 | |
| SCHEMBL9018485 | 0.89 | GABRA5 (0.49) | MMP8MMP12MMP13MAPTP4HTM | |
| SCHEMBL9018172 | 0.87 | MMP8 (0.47) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9139049 | 0.85 | P4HTM (0.50) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9018335 | 0.85 | P4HTM (0.60) | MMP8MMP13KMT2AMEN1MAPT | |
| SCHEMBL9018160 | 0.83 | GABRA5 (0.51) | MAPTP4HTMHDAC1GABRA5NPC1 | |
| SCHEMBL9018260 | 0.82 | KMT2A (0.54) | KMT2AMEN1MAPTP4HTMGLA | |
| SCHEMBL7871632 | 0.82 | KMT2A (0.51) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL7862742 | 0.82 | KMT2A (0.51) | MMP8MMP12MMP13KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |