Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
| ▸ | ACACA | Q13085 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018493 | 0.93 | MMP8 (0.49) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9018094 | 0.89 | CXCR1 (0.43) | OPRM1OPRD1 | |
| SCHEMBL9018410 | 0.89 | P4HTM (0.47) | MMP8MMP12MMP13NOX1P4HTM | |
| SCHEMBL9018064 | 0.87 | MMP8 (0.46) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9140188 | 0.86 | P4HTM (0.50) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9018330 | 0.84 | P4HTM (0.60) | MMP8MMP13KMT2AMEN1P4HTM | |
| SCHEMBL9018043 | 0.83 | GABRA5 (0.47) | NOX1P4HTMOPRM1OPRD1HDAC1 | |
| SCHEMBL8870184 | 0.83 | KMT2A (0.46) | MMP8MMP12MMP13KMT2AMEN1 | |
| SCHEMBL9018037 | 0.83 | KMT2A (0.53) | KMT2AMEN1P4HTMOPRM1NPC1 | |
| SCHEMBL9018418 | 0.83 | CXCR2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |