Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018063 | 0.94 | LMNA (0.44) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9018081 | 0.92 | LMNA (0.39) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9018549 | 0.91 | LMNA (0.43) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9018069 | 0.91 | MEN1 (0.46) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9017984 | 0.90 | ALDH1A1 (0.47) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9018443 | 0.89 | CA1 (0.37) | LMNAALDH1A1POLBP4HTMEGFR | |
| SCHEMBL9018026 | 0.89 | P4HTM (0.40) | LMNAALDH1A1P4HTMEGFROPRM1 | |
| SCHEMBL9018110 | 0.89 | ALDH1A1 (0.46) | LMNAALDH1A1POLBP4HTMOPRM1 | |
| SCHEMBL9018475 | 0.89 | CA1 (0.47) | ALDH1A1POLBP4HTMOPRM1OPRD1 | |
| SCHEMBL9018453 | 0.89 | HSD17B10 (0.48) | LMNAALDH1A1POLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |