Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018184 | 0.94 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018156 | 0.92 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018111 | 0.92 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7871643 | 0.92 | KMT2A (0.51) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018425 | 0.91 | KMT2A (0.47) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018090 | 0.90 | KMT2A (0.50) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018558 | 0.89 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018242 | 0.87 | SMN1; SMN2 (0.43) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7862785 | 0.87 | LMNA (0.52) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018427 | 0.86 | CA1 (0.53) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |