Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018029 | 0.97 | MEN1 (0.50) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL9018179 | 0.94 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MCHR1P4HTM | |
| SCHEMBL9018225 | 0.93 | HSP90AA1 (0.47) | NPC1RAB9ASMN1; SMN2MAPTP4HTM | |
| SCHEMBL9018507 | 0.93 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL9018274 | 0.92 | RAB9A (0.48) | NPC1RAB9ASMN1; SMN2MAPTP4HTM | |
| SCHEMBL9018429 | 0.92 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL9018132 | 0.91 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL9017989 | 0.91 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL9018282 | 0.91 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2MAPTP4HTM | |
| SCHEMBL9018302 | 0.91 | CA1 (0.50) | NPC1RAB9ASMN1; SMN2P4HTMPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |