Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018274 | 0.95 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018085 | 0.95 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018007 | 0.94 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018088 | 0.93 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018133 | 0.92 | CA1 (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018119 | 0.92 | PPARA (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018255 | 0.92 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018296 | 0.92 | HTT (0.55) | RAB9AALDH1A1HDAC2HDAC8HDAC6 | |
| SCHEMBL9018066 | 0.92 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9018232 | 0.91 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |