Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018511 | 0.93 | KMT2A (0.51) | RAB9ANPC1BCL2L1MCL1ALDH1A1 | |
| SCHEMBL9018249 | 0.92 | CA1 (0.57) | CA1CA2CA7CA9CA14 | |
| SCHEMBL9018104 | 0.89 | BCL2L1 (0.48) | RAB9ANPC1BCL2L1MCL1MAPT | |
| SCHEMBL9018146 | 0.88 | CA1 (0.56) | CA1CA2CA7CA9CA14 | |
| SCHEMBL9138369 | 0.87 | CA1 (0.57) | CA1CA2CA7CA9CA14 | |
| SCHEMBL9018112 | 0.87 | LMNA (0.51) | CA1CA2CA9RAB9ANPC1 | |
| SCHEMBL9018402 | 0.87 | POLB (0.45) | RAB9ANPC1BCL2L1MCL1ALDH1A1 | |
| SCHEMBL9018065 | 0.86 | BCL2L1 (0.54) | RAB9ANPC1BCL2L1MCL1ALDH1A1 | |
| SCHEMBL9018240 | 0.86 | BCL2L1 (0.52) | RAB9ANPC1BCL2L1MCL1MAPT | |
| SCHEMBL9018305 | 0.86 | BCL2L1 (0.46) | CA1CA2CA9RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |