Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ENPP3 | O14638 | 8/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 7/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018221 | 0.89 | LMNA (0.43) | LMNASMN1; SMN2TSHRMAPK1MEN1 | |
| SCHEMBL7869495 | 0.87 | LMNA (0.45) | LMNASMN1; SMN2TSHRMAPK1MEN1 | |
| SCHEMBL9018314 | 0.85 | MAPT (0.49) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9018503 | 0.85 | HSD17B10 (0.50) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7870524 | 0.85 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TSHRMAPK1MEN1 | |
| SCHEMBL9138365 | 0.85 | LMNA (0.52) | LMNASMN1; SMN2TSHRMAPK1MEN1 | |
| SCHEMBL9018193 | 0.83 | LMNA (0.53) | LMNASMN1; SMN2TSHRKMT2AHTT | |
| SCHEMBL9018308 | 0.81 | P4HTM (0.46) | SMN1; SMN2MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL9018162 | 0.81 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL9138724 | 0.81 | P4HTM (0.61) | LMNASMN1; SMN2TSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |