Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018395 | 0.90 | MMP1 (0.61) | MMP1MMP2MMP9MAOAMAOB | |
| SCHEMBL9567391 | 0.88 | SMN1; SMN2 (0.58) | MMP1MMP2MMP9MAOAMAOB | |
| SCHEMBL9018321 | 0.88 | MMP1 (0.49) | MMP1MMP2MMP9MAOAMAOB | |
| SCHEMBL11304615 | 0.88 | MMP1 (0.63) | MMP1MMP2MMP9HDAC2MAOA | |
| SCHEMBL11304619 | 0.88 | MMP1 (0.63) | MMP1MMP2MMP9HDAC2MAOA | |
| SCHEMBL9018291 | 0.87 | MMP1 (0.51) | MMP1MMP2MMP9HDAC2MAOA | |
| SCHEMBL9018405 | 0.86 | HDAC3 (0.54) | MMP1MMP2MMP9HDAC8HDAC2 | |
| SCHEMBL9018385 | 0.86 | MMP1 (0.47) | MMP1MMP2MMP9HDAC2MAOA | |
| SCHEMBL9018355 | 0.85 | MMP1 (0.65) | MMP1MMP2MMP9MAOAACHE | |
| SCHEMBL9018438 | 0.84 | LMNA (0.58) | MAOAMAOBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600949-B1 | NEW 3,5-DI-TERT.BUTYL-4-HYDROXYPHENYL DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1996-01-10 | — | — | EP | disclosed |
| EP-0600949-A1 | NEW 3,5-DI-TERT.BUTYL-4-HYDROXYPHENYL DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM. | BOEHRINGER MANNHEIM GMBH (DE) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993004035-A1 | NEW 3,5-DI-TERT.BUTYL-4-HYDROXYPHENYL DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1993-03-04 | — | — | WO | disclosed |
| EP-0527458-A1 | New 3,5-di-tert.-butyl-4-hydroxyphenyl derivatives, process for their preparation and pharmaceutical compounds | Roche Diagnostics GmbH (DE) | 1993-02-17 | — | — | EP | disclosed |