Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018399 | 0.94 | HSD17B10 (0.45) | LMNAALDH1A1POLBHSD17B10RAB9A | |
| SCHEMBL9018443 | 0.93 | CA1 (0.37) | LMNAALDH1A1POLBCA1CA2 | |
| SCHEMBL9018549 | 0.90 | LMNA (0.43) | LMNAALDH1A1POLBRAB9AMMP2 | |
| SCHEMBL9018389 | 0.90 | LMNA (0.41) | LMNAALDH1A1POLBHSD17B10RAB9A | |
| SCHEMBL9018176 | 0.89 | LMNA (0.47) | LMNAALDH1A1POLBRAB9AMMP2 | |
| SCHEMBL9018030 | 0.88 | LMNA (0.39) | LMNAALDH1A1POLBMMP2 | |
| SCHEMBL9141719 | 0.88 | P4HTM (0.41) | LMNAALDH1A1POLBHSD17B10RAB9A | |
| SCHEMBL9018364 | 0.86 | ALDH1A1 (0.45) | LMNAALDH1A1POLBHSD17B10RAB9A | |
| SCHEMBL9017984 | 0.86 | ALDH1A1 (0.47) | LMNAALDH1A1POLBHSD17B10RAB9A | |
| SCHEMBL9018401 | 0.86 | ALDH1A1 (0.41) | LMNAALDH1A1POLBHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |