Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018323 | 0.91 | RAB9A (0.50) | RAB9AMCL1BCL2L1GAAMAPT | |
| SCHEMBL9018106 | 0.87 | MCL1 (0.59) | MCL1BCL2L1P4HTMMMP2MMP13 | |
| SCHEMBL7870464 | 0.85 | BCL2L1 (0.45) | RAB9AMCL1BCL2L1GAAMAPT | |
| SCHEMBL9516252 | 0.83 | BCL2L1 (0.50) | RAB9AMCL1BCL2L1GAAP4HTM | |
| SCHEMBL7871631 | 0.82 | P4HTM (0.52) | P4HTMMMP2MMP9MMP14LMNA | |
| SCHEMBL8868192 | 0.82 | P4HTM (0.49) | RAB9AMCL1BCL2L1GAAMAPT | |
| SCHEMBL9143139 | 0.81 | P4HTM (0.48) | RAB9AMCL1BCL2L1P4HTMMMP2 | |
| SCHEMBL9017985 | 0.80 | P4HTM (0.66) | TDP1P4HTMMMP2MMP9MMP8 | |
| SCHEMBL8868123 | 0.80 | BCL2L1 (0.49) | MCL1BCL2L1MAPTP4HTMMMP2 | |
| SCHEMBL9018452 | 0.79 | MCL1 (0.55) | MCL1BCL2L1P4HTMMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |