Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 9/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868123 | 0.90 | BCL2L1 (0.49) | P4HTMMCL1BCL2L1MAPK14KDR | |
| SCHEMBL8869647 | 0.87 | PGR (0.50) | MAPK14KDRRAB9AMAPTGAA | |
| SCHEMBL9143139 | 0.85 | P4HTM (0.48) | P4HTMMCL1BCL2L1KDRMMP2 | |
| SCHEMBL8870003 | 0.84 | P4HTM (0.56) | P4HTMMCL1BCL2L1KDRRAB9A | |
| SCHEMBL8868467 | 0.82 | P4HTM (0.71) | P4HTMKDRMMP2MMP9MMP8 | |
| SCHEMBL9516252 | 0.82 | BCL2L1 (0.50) | P4HTMMCL1BCL2L1MAPK14MMP2 | |
| SCHEMBL9018320 | 0.82 | RAB9A (0.49) | P4HTMMCL1BCL2L1MMP2MMP3 | |
| SCHEMBL8869868 | 0.81 | P4HTM (0.66) | P4HTMRAB9A | |
| SCHEMBL7870464 | 0.80 | BCL2L1 (0.45) | MCL1BCL2L1MAPK14MMP2MMP3 | |
| SCHEMBL8869937 | 0.79 | P4HTM (0.52) | P4HTMMCL1BCL2L1KDRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |