Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.48 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.36 |
| ▸ | ME1 | P48163 | 1/20 | 0.36 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705028 | 0.91 | KARS1 (0.45) | KARS1SYK | |
| SCHEMBL1704925 | 0.84 | KARS1 (0.47) | KARS1SYK | |
| SCHEMBL1704465 | 0.83 | KARS1 (0.63) | KARS1 | |
| SCHEMBL901988 | 0.81 | KARS1 (0.55) | KARS1 | |
| SCHEMBL901857 | 0.80 | KARS1 (0.57) | KARS1 | |
| SCHEMBL901935 | 0.78 | KARS1 (0.65) | KARS1 | |
| SCHEMBL902224 | 0.78 | KARS1 (0.55) | KARS1 | |
| SCHEMBL1704272 | 0.77 | KARS1 (0.74) | KARS1 | |
| SCHEMBL901439 | 0.77 | KARS1 (0.55) | KARS1SYK | |
| SCHEMBL901800 | 0.77 | KARS1 (0.78) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |