Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901988 | 0.92 | KARS1 (0.55) | KARS1DYRK1ASLC6A7 | |
| SCHEMBL901752 | 0.88 | KARS1 (0.73) | KARS1DYRK1APRKD1SLC6A7PRKD2 | |
| SCHEMBL1704675 | 0.88 | KARS1 (0.51) | KARS1 | |
| SCHEMBL1704555 | 0.86 | KARS1 (0.46) | KARS1 | |
| SCHEMBL902003 | 0.86 | KARS1 (0.61) | KARS1PRKD1SLC6A7PRKD2 | |
| SCHEMBL902013 | 0.85 | KARS1 (0.58) | KARS1PRKD1PRKD2 | |
| SCHEMBL1704272 | 0.85 | KARS1 (0.74) | KARS1DYRK1ASLC6A7 | |
| SCHEMBL902060 | 0.84 | KARS1 (0.53) | KARS1DYRK1ASLC6A7 | |
| SCHEMBL902071 | 0.84 | KARS1 (0.72) | KARS1 | |
| SCHEMBL902224 | 0.84 | KARS1 (0.55) | KARS1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |