Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018379 | 0.86 | P4HTM (0.61) | P4HTMSCN9ASCN5ANNMTHDAC1 | |
| SCHEMBL7870518 | 0.83 | P4HTM (0.64) | P4HTM | |
| SCHEMBL9018398 | 0.81 | GABRA5 (0.55) | P4HTMCXCR1CXCR2 | |
| SCHEMBL9017985 | 0.81 | P4HTM (0.66) | P4HTMHDAC1HDAC6 | |
| SCHEMBL9018056 | 0.80 | P4HTM (0.63) | P4HTMCXCR2EPHX2 | |
| SCHEMBL9018045 | 0.79 | P4HTM (0.50) | P4HTMHDAC1CXCR2EPHX2 | |
| SCHEMBL9018503 | 0.79 | HSD17B10 (0.50) | P4HTM | |
| SCHEMBL9018459 | 0.78 | KMT2A (0.51) | — | |
| SCHEMBL9018004 | 0.78 | P4HTM (0.48) | P4HTMEPHX2 | |
| SCHEMBL9018542 | 0.77 | GABRA5 (0.49) | P4HTMHDAC1CXCR2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | claimed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | claimed |
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |