Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895180 | 0.78 | TLR7 (0.46) | NOS3NOS2TLR7 | |
| SCHEMBL3140455 | 0.77 | MAP4K4 (0.63) | NOS3NOS2MAP4K4TLR7RIPK1 | |
| SCHEMBL28726696 | 0.77 | NPC1 (0.49) | NOS3NOS2MAP4K4MAPK1DYRK1A | |
| SCHEMBL810884 | 0.76 | NOS3 (0.61) | NOS3NOS2GRM5TSHRMAPK1 | |
| SCHEMBL322548 | 0.75 | HSD17B10 (0.50) | NOS3NOS2TLR7TSHRMAPK1 | |
| SCHEMBL972297 | 0.75 | HSD11B1 (0.45) | NOS3NOS2MAPK1GSK3BMAT2A | |
| SCHEMBL29888283 | 0.75 | MKNK1 (0.54) | MAP4K4TLR7RIPK1TOP1KIF11 | |
| SCHEMBL7089225 | 0.74 | NOS3 (0.51) | NOS3NOS2TSHRMAPK1GSK3B | |
| SCHEMBL24363083 | 0.74 | KDM4E (0.54) | NOS3NOS2TLR7GRM5MAPK1 | |
| SCHEMBL5685446 | 0.73 | NOS3 (0.50) | NOS3NOS2TSHRMAPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900665-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-08-05 | — | — | EP | disclosed |