Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.61 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901752 | 0.89 | KARS1 (0.73) | KARS1SLC6A7PRKD1PRKD2 | |
| SCHEMBL902071 | 0.89 | KARS1 (0.72) | KARS1 | |
| SCHEMBL1704341 | 0.88 | KARS1 (0.55) | KARS1 | |
| SCHEMBL902013 | 0.87 | KARS1 (0.58) | KARS1SMG1PRKD1PRKD2 | |
| SCHEMBL901988 | 0.87 | KARS1 (0.55) | KARS1SLC6A7FAAH | |
| SCHEMBL1704272 | 0.87 | KARS1 (0.74) | KARS1SLC6A7 | |
| SCHEMBL901421 | 0.87 | KARS1 (0.82) | KARS1SLC6A7FAAHPRKD1PRKD2 | |
| SCHEMBL901757 | 0.86 | KARS1 (0.66) | KARS1 | |
| SCHEMBL902224 | 0.86 | KARS1 (0.55) | KARS1SMG1LMNAMAPK1 | |
| SCHEMBL901857 | 0.86 | KARS1 (0.57) | KARS1SLC6A7PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |