Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 7/20 | 0.49 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 10/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704492 | 0.93 | KARS1 (0.51) | KARS1IDH2SYK | |
| SCHEMBL901924 | 0.91 | IDH2 (0.48) | IDH2SYK | |
| SCHEMBL902758 | 0.88 | KARS1 (0.64) | KARS1SYKKMO | |
| SCHEMBL1704255 | 0.87 | KARS1 (0.52) | KARS1IDH2SYK | |
| SCHEMBL1704715 | 0.85 | IDH2 (0.40) | IDH2SYKNR3C2 | |
| SCHEMBL1705304 | 0.85 | KARS1 (0.47) | KARS1SYK | |
| SCHEMBL1704269 | 0.83 | KARS1 (0.47) | KARS1 | |
| SCHEMBL901917 | 0.83 | KARS1 (0.53) | KARS1IDH2SYKKMONR3C2 | |
| SCHEMBL902073 | 0.80 | KARS1 (0.71) | KARS1IDH2SYKNR3C2 | |
| SCHEMBL901883 | 0.80 | AURKA (0.56) | KARS1IDH2SYKKMONR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |