Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.55 |
| ▸ | SYK | P43405 | 7/20 | 0.47 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902073 | 0.84 | KARS1 (0.71) | AURKAKARS1SYKNR3C2IDH2 | |
| SCHEMBL901917 | 0.83 | KARS1 (0.53) | KARS1SYKNR3C2IDH2KMO | |
| SCHEMBL901722 | 0.81 | KARS1 (0.52) | AURKAKARS1 | |
| SCHEMBL901864 | 0.80 | KARS1 (0.49) | KARS1SYKNR3C2IDH2KMO | |
| SCHEMBL902909 | 0.77 | KARS1 (0.63) | AURKAKARS1SYKIDH2 | |
| SCHEMBL901724 | 0.76 | KARS1 (0.57) | KARS1SYKIDH2KMO | |
| SCHEMBL10268803 | 0.76 | KARS1 (0.71) | KARS1SYKIDH2 | |
| SCHEMBL902700 | 0.76 | KARS1 (0.54) | KARS1SYKNR3C2 | |
| SCHEMBL27160775 | 0.75 | NR3C2 (0.53) | AURKANR3C2KMO | |
| SCHEMBL901891 | 0.74 | KARS1 (0.73) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |