SCHEMBL9018802

SCHEMBL9018802

Clc1cccc(Cl)c1SC(Cl)Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.39
CYP2A6 P11509 2/20 0.39
TSHR P16473 4/20 0.38
LMNA P02545 3/20 0.38
ALDH1A1 P00352 6/20 0.36
NR4A2 P43354 1/20 0.36
TDP1 Q9NUW8 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SOD1 P00441 1/20 0.33
AKR1B1 P15121 1/20 0.33
CYP3A4 P08684 2/20 0.32
CYP2D6 P10635 2/20 0.32
PNMT P11086 2/20 0.32
NFKB1 P19838 1/20 0.32
TP53 P04637 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8484389 0.89 CYP1A2 (0.32) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL13816926 0.77 CYP1A2 (0.38) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL9018794 0.72 TSHR (0.43) TSHRLMNAALDH1A1TDP1CYP3A4
SCHEMBL226109 0.71 CYP2A6 (0.47) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL28715207 0.71 CYP1A2 (0.47) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL6955752 0.70 TSHR (0.41) TSHRLMNAALDH1A1MEN1KMT2A
SCHEMBL4128904 0.69 CYP1A2 (0.45) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL6558617 0.69 ALDH1A1 (0.47) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL10829734 0.68 TYMP (0.43) TSHRLMNAALDH1A1AKR1B1
SCHEMBL24211432 0.67 CYP1A2 (0.43) CYP1A2CYP2A6TSHRLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0742201-A1 PROCESS FOR PRODUCING AROMATIC OR HETEROAROMATIC SULFUR COMPOUNDS SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1996-11-13 EP disclosed