Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 9/20 | 0.63 |
| ▸ | SYK | P43405 | 6/20 | 0.54 |
| ▸ | IDH2 | P48735 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268803 | 0.81 | KARS1 (0.71) | KARS1SYKIDH2 | |
| SCHEMBL902672 | 0.80 | KARS1 (0.74) | KARS1SYKABL1 | |
| SCHEMBL17147632 | 0.79 | SYK (0.50) | KARS1SYKIDH2AURKA | |
| SCHEMBL902073 | 0.79 | KARS1 (0.71) | KARS1SYKIDH2AURKA | |
| SCHEMBL901740 | 0.78 | KARS1 (1.00) | KARS1SYK | |
| SCHEMBL1704454 | 0.78 | KARS1 (0.50) | KARS1SYKIDH2AURKA | |
| SCHEMBL904195 | 0.78 | SYK (0.52) | KARS1SYKIDH2AURKA | |
| SCHEMBL901724 | 0.77 | KARS1 (0.57) | KARS1SYKIDH2 | |
| SCHEMBL901883 | 0.77 | AURKA (0.56) | KARS1SYKIDH2AURKA | |
| SCHEMBL901727 | 0.76 | KARS1 (1.00) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |