Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704879 | 0.79 | KARS1 (0.68) | KARS1JAK2TYK2JAK1SIRT2 | |
| SCHEMBL902678 | 0.78 | KCNK3 (0.59) | JAK2TYK2KCNK3KMT2AKDM4E | |
| SCHEMBL45148 | 0.77 | KMT2A (0.73) | JAK2TYK2NAMPTSIRT2KMT2A | |
| SCHEMBL29238994 | 0.75 | KMT2A (0.71) | JAK2TYK2NAMPTSIRT2KMT2A | |
| SCHEMBL30533391 | 0.75 | KMT2A (0.71) | JAK2TYK2NAMPTSIRT2KMT2A | |
| SCHEMBL1704285 | 0.75 | KDR (0.48) | KARS1JAK2TYK2JAK1SIRT2 | |
| SCHEMBL901298 | 0.73 | KARS1 (0.64) | KARS1JAK2TYK2JAK1SIRT2 | |
| SCHEMBL901763 | 0.73 | KARS1 (1.00) | KARS1PRKD1 | |
| SCHEMBL24150224 | 0.71 | JAK2 (0.60) | JAK2TYK2NAMPTKCNK3KMT2A | |
| SCHEMBL901939 | 0.70 | SYK (0.40) | KARS1JAK2TYK2JAK1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |