Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 10/20 | 0.68 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901763 | 0.81 | KARS1 (1.00) | KARS1PRKD1 | |
| SCHEMBL901421 | 0.81 | KARS1 (0.82) | KARS1SIRT2MAPK8MAPK10JAK2 | |
| SCHEMBL901941 | 0.79 | KARS1 (0.56) | KARS1SIRT2MAPK8MAPK10JAK2 | |
| SCHEMBL901298 | 0.78 | KARS1 (0.64) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL901833 | 0.78 | KARS1 (0.72) | KARS1PDGFRBPDGFRAABL1BCR | |
| SCHEMBL901769 | 0.77 | KARS1 (0.60) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL902036 | 0.77 | KARS1 (0.81) | KARS1MAPK8MAPK10PDGFRBPDGFRA | |
| SCHEMBL901595 | 0.77 | KARS1 (0.86) | KARS1PRKD3PRKD1 | |
| SCHEMBL1704251 | 0.76 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL901620 | 0.75 | KARS1 (1.00) | KARS1PRKD3PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |