Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901939 | 0.78 | SYK (0.40) | LYNSRCBTKKARS1KMT2A | |
| SCHEMBL901654 | 0.75 | KDR (0.47) | KDRLYNSRCBTKKARS1 | |
| SCHEMBL901941 | 0.75 | KARS1 (0.56) | KDRSRCKARS1KMT2AJAK2 | |
| SCHEMBL2791072 | 0.73 | KDR (0.56) | KDRLYNSRCBTKMEN1 | |
| SCHEMBL2789410 | 0.73 | KDR (0.56) | KDRMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL1704286 | 0.71 | KDR (0.39) | KDRLYNSRCBTKMEN1 | |
| SCHEMBL901737 | 0.70 | CRHBP (0.50) | MEN1ALDH1A1HPGDKMT2ACYP19A1 | |
| SCHEMBL5787755 | 0.70 | KDR (0.47) | KDRMEN1ALDH1A1HPGDKMT2A | |
| Biphenyl SCHEMBL27557877 | 0.70 | ALDH1A1 (0.51) | KDRLYNSRCBTKMEN1 | |
| SCHEMBL902727 | 0.69 | CHEK1 (0.56) | KDRLYNSRCBTKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |