Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.72 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704434 | 0.96 | KARS1 (0.68) | KARS1CDK1CDK2SMG1SYK | |
| SCHEMBL901697 | 0.87 | KARS1 (0.65) | KARS1SYK | |
| SCHEMBL902051 | 0.87 | KARS1 (0.55) | KARS1SYKMAP3K12 | |
| SCHEMBL1705645 | 0.87 | KARS1 (0.56) | KARS1SYK | |
| SCHEMBL902071 | 0.86 | KARS1 (0.72) | KARS1 | |
| SCHEMBL1704409 | 0.86 | KARS1 (0.73) | KARS1SMG1SYK | |
| SCHEMBL901944 | 0.86 | KARS1 (0.75) | KARS1CDK1CDK2SMG1SYK | |
| SCHEMBL901785 | 0.85 | KARS1 (0.53) | KARS1CDK1CDK2SMG1 | |
| SCHEMBL901674 | 0.84 | KARS1 (0.62) | KARS1SYK | |
| SCHEMBL901824 | 0.84 | KARS1 (1.00) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |